Prime Medicine (PRME) Cash Flow: Operating & Free Cash Flow

Prime Medicine Cash Flow Statement Analysis

Values in millions USD

Income Statement Balance Sheet Cash Flow Ratios

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Cash flow statement showing operating, investing, and financing activities for Prime Medicine, Inc. (PRME) - Annual data in millions USD
Breakdown	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020	FY 2019
Period ending	Dec 2025	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020	Dec 2019
Operating Activities
Net Income	-201.14	-195.88	-198.13	-121.82	-165.37	-3.41	-2.53
Depreciation & Amortization	5.38	6.13	4.65	2.22	0.57	0.04	0.00
Deferred Income Tax	0.00	0.00	-0.28	-0.96	-0.62	1.87	0.00
Stock Based Compensation	29.27	26.07	13.91	6.46	1.75	0.39	0.00
Change in Working Capital	-5.34	31.08	2.65	-35.40	31.18	0.16	0.49
Change in Accounts Payable	1.00	-5.26	9.14	2.46	1.19	0.25	0.00
Change in Other Working Capital	-6.34	36.33	-6.49	-37.86	29.99	-0.09	0.49
Other Operating Activities	9.27	9.75	11.79	17.68	98.42	8.14	0.70
Net Cash from Operating Activities	-162.56	-122.87	-165.41	-131.83	-34.08	-5.54	-1.33
Investing Activities
Capital Expenditures	-4.53	-7.29	-8.72	-16.10	-4.15	-0.64	0.00
Purchases of Investments	-205.41	-129.45	-104.95	-123.34	-81.98	0.00	0.00
Sales/Maturities of Investments	101.18	204.20	132.56	93.00	13.00	0.00	0.00
Other Investing Activities	0.00	1.00	-0.17	-0.67	-0.50	-0.42	0.00
Net Cash from Investing Activities	-108.76	68.46	18.71	-47.10	-73.63	-1.06	0.00
Financing Activities
Common Stock Issued	139.51	170.14	0.66	185.32	0.00	0.00	9.98
Other Financing Activities	12.00	25.74	0.00	-3.82	269.28	-0.02	0.00
Net Cash from Financing Activities	151.51	195.88	0.66	181.49	269.28	34.93	9.98
Summary
Effect of Forex Changes on Cash	0.00	0.00	0.00	0.00	0.00	0.00	-8.65
Net Change in Cash	-119.82	141.47	-146.05	2.57	161.57	28.33	0.00
Cash at Beginning of Period	196.54	55.07	201.12	198.55	36.98	8.65	0.00
Cash at End of Period	76.72	196.54	55.07	201.12	198.55	36.98	0.00
Free Cash Flow	-167.10	-130.16	-174.14	-147.92	-38.23	-6.18	-1.33

Source: Company financial statements from annual and quarterly filings. Data as of Jun 30, 2026. Data sources and methodology

Frequently Asked Questions About Prime Medicine Cash Flow

What is Prime Medicine's free cash flow?

Prime Medicine had negative free cash flow of $167.09M in fiscal 2025 (fiscal year ended Dec 31, 2025), operating cash flow of −$162.56M minus $4.53M of capital expenditures.

How much does Prime Medicine spend on capital expenditures?

Prime Medicine spent $4.53M on capital expenditures in fiscal 2025, compared with $7.29M a year earlier.

Does Prime Medicine pay dividends or buy back shares?

Prime Medicine's cash flow statement for fiscal 2025 shows no dividend payments or share repurchases.

What is free cash flow?

Free cash flow is operating cash flow minus capital expenditures. It is the cash a company has left for dividends, buybacks, debt repayment or acquisitions after funding its operations and investment. Full definition