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Upstream Bio, Inc.

UPBNASDAQHealthcareBiotechnology

$2.76Today:- (-)1Y −83.93%

As of Oct 16, 2026 close

Market cap
$183.89M
P/E (TTM)
-
Forward P/E
-
Dividend yield
-
52-week range
$3.29$33.68
Volume (live)
-
Avg. volume (3M)
875.05K

Upstream Bio (UPB) Cash Flow Statement

In fiscal 2025 (fiscal year ended Dec 31, 2025), Upstream Bio used $133.28M of cash in operating activities and spent $165.00K on capital expenditures. That left free cash flow of −$133.44M.

Upstream Bio Cash Flow Statement Analysis

Values in millions USD

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Cash flow statement showing operating, investing, and financing activities for Upstream Bio, Inc. (UPB) - Annual data in millions USD
BreakdownFY 2025FY 2024FY 2023FY 2022
Period endingDec 2025Dec 2024Dec 2023Dec 2022
Operating Activities
Net Income-143.44-62.81-20.54-23.87
Depreciation & Amortization0.190.090.060.01
Stock Based Compensation10.336.003.431.28
Change in Working Capital0.591.87-4.313.41
Change in Accounts Receivable-0.06-0.520.31-0.41
Change in Accounts Payable-1.282.021.280.46
Change in Other Working Capital-2.090.37-15.310.15
Other Operating Activities-0.94-4.33-15.310.15
Net Cash from Operating Activities-133.28-59.17-37.93-19.02
Investing Activities
Capital Expenditures-0.17-0.51-0.14-0.08
Purchases of Investments-385.88-290.61-128.990.00
Sales/Maturities of Investments292.56231.6446.290.00
Net Cash from Investing Activities-93.48-59.49-82.84-0.08
Financing Activities
Common Stock Issued2.48272.720.120.00
Other Financing Activities-0.03146.19129.43-0.04
Net Cash from Financing Activities2.44418.91129.559.96
Summary
Net Change in Cash-224.31300.258.78-9.14
Cash at Beginning of Period326.0925.8317.0526.19
Cash at End of Period101.77326.0925.8317.05
Free Cash Flow-133.44-59.68-38.07-19.10

Source: Company financial statements from annual and quarterly filings. Data as of Jun 30, 2026. Data sources and methodology

Frequently Asked Questions About Upstream Bio Cash Flow

What is Upstream Bio's free cash flow?

Upstream Bio had negative free cash flow of $133.44M in fiscal 2025 (fiscal year ended Dec 31, 2025), operating cash flow of −$133.28M minus $165.00K of capital expenditures.

How much does Upstream Bio spend on capital expenditures?

Upstream Bio spent $165.00K on capital expenditures in fiscal 2025, compared with $511.00K a year earlier.

Does Upstream Bio pay dividends or buy back shares?

Upstream Bio's cash flow statement for fiscal 2025 shows no dividend payments or share repurchases.

What is free cash flow?

Free cash flow is operating cash flow minus capital expenditures. It is the cash a company has left for dividends, buybacks, debt repayment or acquisitions after funding its operations and investment. Full definition