Upstream Bio, Inc.
UPBNASDAQHealthcareBiotechnology
As of Oct 15, 2026 close
- Market cap
- $183.89M
- P/E (TTM)
- -
- Forward P/E
- -
- Dividend yield
- -
- 52-week range
- $3.29$33.68
- Volume (live)
- -
- Avg. volume (3M)
- 858.76K
Upstream Bio (UPB) Stock Price & Financial Analysis
Upstream Bio Stock Price Chart
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Financial Metrics & Key Statistics
Fundamental metrics, valuation ratios, and profitability indicators
| Day's Range | $3.29 - $3.56 |
|---|---|
| 52-Week High | $33.68 |
| 52-Week Low | $3.29 |
| Open | $3.44 |
| Volume (last close) | 1.29M |
| Average Volume (3M) | 858.76K |
| Revenue (TTM) | 3.16M |
|---|---|
| Net Income (TTM) | -156.50M |
| Free Cash Flow (TTM) | -136.34M |
| EPS (TTM) | −$2.88 |
| Profit Margin | -4955.67% |
| Operating Margin | -5382.65% |
| Return on Equity (ROE) | -57.76% |
| Debt to Equity | 0.00 |
| Annual Dividend | $0.00 |
|---|---|
| Dividend Yield | 0.00% |
| Market Cap | 183.89M |
|---|---|
| Shares Outstanding | 54.57M |
| Price to Sales (P/S) | 58.23 |
| Price to Book (P/B) | 0.68 |
| EV/EBITDA | -0.66 |
| 50-Day MA | $5.91 |
|---|---|
| 200-Day MA | $10.82 |
| 1-Year Change | −84.87% |
Source: Market prices and company fundamentals. Data as of Oct 15, 2026. Data sources and methodology
Upstream Bio at a Glance
As of the Oct 15, 2026 close, Upstream Bio (UPB) has a market capitalization of $183.89M. The stock trades at 58.2× sales. Over the trailing twelve months it lost $156.50M on revenue of $3.16M and burned $136.34M of free cash flow. Revenue grew 16.0% year over year.
As of its latest reported balance sheet, it holds $79.40M in cash and securities against $954.00K of debt, a net cash position of $78.44M.
Upstream Bio does not currently pay a dividend.
The share price is down 84.9% over the past year. At $3.37 (the Oct 15, 2026 close) it sits near the bottom of its 52-week range of $3.29 to $33.68, below its 200-day moving average of $10.82.
Based on 6 professional analyst ratings from the past 90 days, the consensus is Buy with an average price target of $22.25, 560.2% above the Oct 15, 2026 close.
Frequently Asked Questions About Upstream Bio
What is the current stock price for UPB?
As of the Oct 15, 2026 close, UPB stock trades at $3.37. The 52-week range is $3.29–$33.68, with a day range of $3.29–$3.56.
What is the P/E ratio for UPB?
The P/E ratio (Price-to-Earnings) for UPB is shown in the Key Statistics section. This valuation metric helps compare Upstream Bio, Inc. to industry peers.
Does UPB pay dividends?
Upstream Bio does not currently pay a regular dividend. It reported a net loss over the trailing twelve months, so it has no earnings to distribute. Check the Dividends tab for historical dividend information.
What do analysts recommend for UPB?
Based on ratings from 6 professional analysts over the last 90 days, the consensus for UPB is Buy. The average 12-month price target is $22.25, a 560.2% upside from the Oct 15, 2026 close of $3.37.
What is the market cap of UPB?
As of the Oct 15, 2026 close, Upstream Bio's market capitalization is $183.9M, classifying it as a micro-cap company. Upstream Bio operates in the Healthcare sector within the Biotechnology industry.