| 1 | VRTX | Vertex Pharmaceuticals Incorporated | $535.17 | $136.58B | $12.59B | $4.41B | $17.19 | 1.18M |
| 2 | REGN | Regeneron Pharmaceuticals, Inc. | $819.09 | $86.82B | $15.53B | $4.33B | $40.42 | 728.84K |
| 3 | MRNA | Moderna, Inc. | $202.63 | $80.65B | $2.23B | -$3.15B | −$8.00 | 18.38M |
| 4 | ARGX | argenx SE | $875.76 | $56.51B | $7.20B | $2.23B | $33.83 | 426.02K |
| 5 | ONC | BeOne Medicines AG | $382.27 | $44.27B | $918.45M | $98.26M | $0.85 | 377.61K |
| 6 | RVMD | Revolution Medicines, Inc. | $187.69 | $39.58B | $0.00 | -$1.77B | −$8.97 | 2.24M |
| 7 | RPRX | Royalty Pharma plc | $63.75 | $35.51B | $2.54B | $815.00M | $1.46 | 3.03M |
| 8 | ALNY | Alnylam Pharmaceuticals, Inc. | $227.28 | $31.43B | $4.80B | $807.99M | $5.87 | 1.33M |
| 9 | ROIV | Roivant Sciences Ltd. | $37.45 | $26.99B | $7.53M | -$266.25M | −$0.37 | 7.43M |
| 10 | GMAB | Genmab A/S | $40.00 | $24.68B | $4.13B | $788.20M | $1.58 | 3.76M |
| 11 | INCY | Incyte Corporation | $116.93 | $24.35B | $5.82B | $1.61B | $7.85 | 1.72M |
| 12 | BNTX | BioNTech SE | $89.67 | $22.72B | $2.97B | -$1.89B | −$7.64 | 1.02M |
| 13 | INSM | Insmed Incorporated | $95.06 | $20.66B | $1.14B | -$875.31M | −$4.08 | 2.70M |
| 14 | EXEL | Exelixis, Inc. | $65.31 | $16.96B | $2.44B | $860.62M | $3.17 | 2.28M |
| 15 | ASND | Ascendis Pharma A/S | $242.99 | $16.60B | $1.18B | $847.05M | $13.31 | 873.12K |
| 16 | HALO | Halozyme Therapeutics, Inc. | $124.54 | $15.10B | $1.66B | $413.60M | $3.42 | 2.60M |
| 17 | JAZZ | Jazz Pharmaceuticals plc | $214.65 | $14.90B | $4.60B | $940.76M | $14.58 | 801.57K |
| 18 | BBIO | BridgeBio Pharma, Inc. | $68.12 | $13.34B | $713.07M | -$691.87M | −$3.57 | 2.90M |
| 19 | MDGL | Madrigal Pharmaceuticals, Inc. | $453.34 | $13.21B | $1.28B | -$325.10M | −$12.61 | 277.24K |
| 20 | CORT | Corcept Therapeutics Incorporated | $107.50 | $12.73B | $830.81M | $54.03M | $0.47 | 1.38M |
| 21 | SMMT | Summit Therapeutics Inc. | $15.55 | $12.10B | $0.00 | -$856.09M | −$1.12 | 6.79M |
| 22 | TECH | Bio-Techne Corporation | $72.62 | $11.40B | $1.22B | $181.86M | $1.16 | 3.11M |
| 23 | BMRN | BioMarin Pharmaceutical Inc. | $56.63 | $10.99B | $3.41B | $72.97M | $0.37 | 2.32M |
| 24 | KYMR | Kymera Therapeutics, Inc. | $110.85 | $10.88B | $105.00M | -$299.60M | −$3.21 | 842.37K |
| 25 | APGE | Apogee Therapeutics, Inc. | $135.07 | $10.19B | $0.00 | -$294.37M | −$4.43 | 1.51M |
| 26 | PTGX | Protagonist Therapeutics, Inc. | $139.53 | $9.91B | $281.99M | $82.91M | $1.23 | 802.07K |
| 27 | KRYS | Krystal Biotech, Inc. | $320.13 | $9.81B | $440.48M | $241.47M | $7.99 | 289.50K |
| 28 | NUVL | Nuvalent, Inc. | $123.96 | $9.75B | $0.00 | -$450.07M | −$6.05 | 0.00 |
| 29 | PCVX | Vaxcyte, Inc. | $62.85 | $9.08B | $0.00 | -$1.06B | −$7.65 | 3.11M |
| 30 | CAI | Caris Life Sciences, Inc. | $31.71 | $8.97B | $989.61M | $104.63M | $0.36 | 4.56M |
| 31 | CRNX | Crinetics Pharmaceuticals, Inc. | $84.95 | $8.97B | $42.16M | -$501.61M | −$5.04 | 1.63M |
| 32 | IBRX | ImmunityBio, Inc. | $8.31 | $8.73B | $165.79M | -$992.36M | −$0.99 | 15.20M |
| 33 | ARWR | Arrowhead Pharmaceuticals, Inc. | $58.36 | $8.37B | $669.50M | -$319.95M | −$2.27 | 2.24M |
| 34 | TGTX | TG Therapeutics, Inc. | $53.16 | $8.36B | $799.54M | $441.49M | $2.77 | 1.72M |
| 35 | CYTK | Cytokinetics, Incorporated | $62.33 | $8.23B | $67.67M | -$894.00M | −$7.18 | 2.10M |
| 36 | AXSM | Axsome Therapeutics, Inc. | $156.07 | $8.08B | $776.57M | -$191.64M | −$3.76 | 820.90K |
| 37 | SYRE | Spyre Therapeutics, Inc. | $92.33 | $7.82B | $90.49M | -$178.92M | −$2.39 | 1.46M |
| 38 | PRAX | Praxis Precision Medicines, Inc. | $258.92 | $7.54B | $0.00 | -$339.13M | −$13.23 | 544.14K |
| 39 | IONS | Ionis Pharmaceuticals, Inc. | $43.91 | $7.26B | $873.76M | -$564.78M | −$3.46 | 3.80M |
| 40 | ABVX | ABIVAX Société Anonyme | $90.23 | $7.19B | $2.22M | -$449.82M | −$5.98 | 1.38M |
| 41 | LGND | Ligand Pharmaceuticals Incorporated | $307.82 | $6.72B | $290.54M | $197.22M | $9.50 | 253.82K |
| 42 | IOVA | Iovance Biotherapeutics, Inc. | $14.14 | $6.37B | $324.97M | -$289.52M | −$0.71 | 16.70M |
| 43 | RYTM | Rhythm Pharmaceuticals, Inc. | $90.90 | $6.24B | $239.92M | -$205.35M | −$3.05 | 752.08K |
| 44 | CNTA | Centessa Pharmaceuticals plc | $40.50 | $6.22B | $0.00 | -$250.64M | −$1.78 | 0.00 |
| 45 | BLTE | Belite Bio, Inc | $150.27 | $6.04B | $0.00 | -$102.36M | −$2.74 | 149.56K |
| 46 | IMVT | Immunovant, Inc. | $29.10 | $5.98B | $7.09M | -$538.22M | −$2.82 | 1.59M |
| 47 | PTCT | PTC Therapeutics, Inc. | $63.04 | $5.80B | $1.01B | -$38.38M | −$0.45 | 1.20M |
| 48 | MANE | Veradermics, Incorporated | $138.49 | $5.60B | $0.00 | -$92.68M | −$2.46 | 885.13K |
| 49 | CGON | CG Oncology, Inc. | $62.58 | $5.52B | $6.23M | -$224.38M | −$2.75 | 1.03M |
| 50 | SRRK | Scholar Rock Holding Corporation | $41.96 | $5.48B | $0.00 | -$408.59M | −$3.55 | 2.30M |
| 51 | KOD | Kodiak Sciences Inc. | $85.78 | $5.37B | $0.00 | -$237.27M | −$4.09 | 2.93M |
| 52 | COGT | Cogent Biosciences, Inc. | $31.31 | $5.36B | $0.00 | -$377.18M | −$2.36 | 2.23M |
| 53 | MIRM | Mirum Pharmaceuticals, Inc. | $83.10 | $5.27B | $618.07M | -$860.21M | −$15.00 | 830.03K |
| 54 | ORKA | Oruka Therapeutics, Inc. | $81.15 | $5.10B | $0.00 | -$132.89M | −$2.45 | 996.76K |
| 55 | TVTX | Travere Therapeutics, Inc. | $52.43 | $4.90B | $591.33M | -$43.46M | −$0.46 | 1.86M |
| 56 | CRSP | CRISPR Therapeutics AG | $49.99 | $4.82B | $13.21M | -$475.90M | −$5.02 | 1.68M |
| 57 | DNTH | Dianthus Therapeutics, Inc. | $78.58 | $4.40B | $1.90M | -$29.91M | −$0.67 | 1.02M |
| 58 | ARQT | Arcutis Biotherapeutics, Inc. | $32.20 | $4.38B | $463.98M | $28.52M | $0.21 | 3.22M |
| 59 | ERAS | Erasca, Inc. | $14.04 | $4.37B | $0.00 | -$287.22M | −$0.97 | 5.13M |
| 60 | EWTX | Edgewise Therapeutics, Inc. | $39.99 | $4.31B | $0.00 | -$197.22M | −$1.86 | 1.72M |
| 61 | TNGX | Tango Therapeutics, Inc. | $27.93 | $4.19B | $53.81M | -$123.72M | −$0.94 | 3.69M |
| 62 | CPRX | Catalyst Pharmaceuticals, Inc. | $31.49 | $4.00B | $596.96M | $221.32M | $1.74 | 0.00 |
| 63 | DFTX | Definium Therapeutics, Inc. | $36.00 | $3.98B | $0.00 | -$353.79M | −$3.59 | 2.43M |
| 64 | RLAY | Relay Therapeutics, Inc. | $18.34 | $3.72B | $10.35M | -$286.04M | −$1.57 | 3.03M |
| 65 | LEGN | Legend Biotech Corporation | $18.90 | $3.66B | $1.27B | -$91.60M | −$0.49 | 2.29M |
| 66 | XENE | Xenon Pharmaceuticals Inc. | $36.50 | $3.64B | $0.00 | -$409.19M | −$4.74 | 2.38M |
| 67 | CELC | Celcuity Inc. | $65.57 | $3.59B | $0.00 | -$226.48M | −$4.33 | 1.58M |
| 68 | ACAD | ACADIA Pharmaceuticals Inc. | $20.31 | $3.51B | $1.14B | $380.48M | $2.21 | 2.16M |
| 69 | DNLI | Denali Therapeutics Inc. | $18.66 | $3.50B | $3.60M | -$511.45M | −$2.83 | 1.91M |
| 70 | ABCL | AbCellera Biologics Inc. | $11.37 | $3.47B | $66.17M | -$164.66M | −$0.55 | 5.12M |
| 71 | TLX | Telix Pharmaceuticals Limited | $9.54 | $3.40B | $2.50B | $83.02M | $0.24 | 473.24K |
| 72 | IDYA | IDEAYA Biosciences, Inc. | $36.12 | $3.33B | $234.13M | -$175.02M | −$1.95 | 858.64K |
| 73 | TARS | Tarsus Pharmaceuticals, Inc. | $72.08 | $3.13B | $606.33M | -$46.48M | −$1.08 | 905.89K |
| 74 | VKTX | Viking Therapeutics, Inc. | $25.83 | $3.00B | $0.00 | -$534.80M | −$4.67 | 7.68M |
| 75 | NRIX | Nurix Therapeutics, Inc. | $25.51 | $2.96B | $701.94M | -$341.35M | −$3.41 | 2.16M |
| 76 | IRON | Disc Medicine, Inc. | $75.03 | $2.90B | $0.00 | -$245.89M | −$6.66 | 1.12M |
| 77 | ELVN | Enliven Therapeutics, Inc. | $41.93 | $2.77B | $0.00 | -$105.93M | −$1.71 | 1.55M |
| 78 | NAMS | NewAmsterdam Pharma Company N.V. | $21.58 | $2.66B | $7.12M | -$259.50M | −$2.17 | 1.62M |
| 79 | ATAI | AtaiBeckley Inc. | $7.35 | $2.65B | $4.47M | -$668.19M | −$2.39 | 16.06M |
| 80 | PGEN | Precigen, Inc. | $6.39 | $2.64B | $85.72M | -$157.71M | −$0.47 | 5.26M |
| 81 | DYN | Dyne Therapeutics, Inc. | $15.77 | $2.61B | $0.00 | -$519.41M | −$3.46 | 3.14M |
| 82 | BEAM | Beam Therapeutics Inc. | $24.56 | $2.56B | $156.03M | -$85.43M | −$0.82 | 1.75M |
| 83 | ADMA | ADMA Biologics, Inc. | $10.95 | $2.52B | $512.27M | $168.96M | $0.70 | 3.23M |
| 84 | VRDN | Viridian Therapeutics, Inc. | $22.82 | $2.46B | $71.13M | -$386.97M | −$4.11 | 2.04M |
| 85 | ZLAB | Zai Lab Limited | $22.04 | $2.46B | $449.61M | -$188.21M | −$1.70 | 834.61K |
| 86 | RCUS | Arcus Biosciences, Inc. | $19.36 | $2.44B | $117.00M | -$452.00M | −$3.88 | 2.12M |
| 87 | MBX | MBX Biosciences, Inc. | $50.46 | $2.41B | $0.00 | -$104.29M | −$2.41 | 614.19K |
| 88 | AUPH | Aurinia Pharmaceuticals Inc. | $17.33 | $2.31B | $311.51M | $314.11M | $2.30 | 831.31K |
| 89 | FTRE | Fortrea Holdings Inc. | $23.92 | $2.26B | $2.68B | -$85.20M | −$0.92 | 1.82M |
| 90 | CLDX | Celldex Therapeutics, Inc. | $28.97 | $2.26B | $112.00K | -$300.59M | −$4.34 | 1.98M |
| 91 | VCEL | Vericel Corporation | $42.97 | $2.25B | $306.30M | $24.22M | $0.47 | 550.02K |
| 92 | BHVN | Biohaven Ltd. | $14.69 | $2.21B | $0.00 | -$586.84M | −$4.48 | 3.29M |
| 93 | AGIO | Agios Pharmaceuticals, Inc. | $37.19 | $2.21B | $98.34M | -$411.29M | −$7.01 | 1.17M |
| 94 | SLS | SELLAS Life Sciences Group, Inc. | $11.35 | $2.15B | $0.00 | -$32.46M | −$0.21 | 6.29M |
| 95 | HRMY | Harmony Biosciences Holdings, Inc. | $36.03 | $2.12B | $959.90M | $181.27M | $3.09 | 1.07M |
| 96 | VERA | Vera Therapeutics, Inc. | $29.05 | $2.09B | $0.00 | -$401.89M | −$5.92 | 2.35M |
| 97 | PHVS | Pharvaris N.V. | $30.61 | $2.08B | $0.00 | -$203.11M | −$3.15 | 770.40K |
| 98 | ZYME | Zymeworks Inc. | $28.44 | $2.08B | $37.13M | -$149.99M | −$2.01 | 1.15M |
| 99 | LKFT | Lakefront Biotherapeutics NV | $31.40 | $2.07B | $1.11B | $668.90M | $10.11 | 328.78K |
| 100 | IMNM | Immunome, Inc. | $18.26 | $2.07B | $0.00 | -$254.32M | −$2.53 | 1.51M |