Spyre Therapeutics, Inc.
SYRENASDAQHealthcareBiotechnology
As of Oct 23, 2026 close
- Market cap
- $7.65B
- P/E (TTM)
- -
- Forward P/E
- -
- Dividend yield
- -
- 52-week range
- $21.15$110.18
- Volume (live)
- -
- Avg. volume (3M)
- 1.45M
Spyre Therapeutics (SYRE) Stock Price & Financial Analysis
Spyre Therapeutics Stock Price Chart
Loading chart...
Financial Metrics & Key Statistics
Fundamental metrics, valuation ratios, and profitability indicators
| Day's Range | $88.69 - $91.90 |
|---|---|
| 52-Week High | $110.18 |
| 52-Week Low | $21.15 |
| Open | $90.71 |
| Volume (last close) | 502.89K |
| Average Volume (3M) | 1.45M |
| Revenue (TTM) | 90.49M |
|---|---|
| Net Income (TTM) | -178.92M |
| Free Cash Flow (TTM) | -208.94M |
| EPS (TTM) | −$2.39 |
| Profit Margin | -197.71% |
| Operating Margin | -266.69% |
| Return on Equity (ROE) | -16.25% |
| Debt to Equity | 0.00 |
| Annual Dividend | $0.00 |
|---|---|
| Dividend Yield | 0.00% |
| Market Cap | 7.65B |
|---|---|
| Shares Outstanding | 84.73M |
| Price to Sales (P/S) | 84.58 |
| Price to Book (P/B) | 6.95 |
| EV/EBITDA | -27.69 |
| 50-Day MA | $91.63 |
|---|---|
| 200-Day MA | $70.66 |
| 1-Year Change | +312.74% |
Source: Market prices and company fundamentals. Data as of Oct 23, 2026. Data sources and methodology
Spyre Therapeutics at a Glance
As of the Oct 23, 2026 close, Spyre Therapeutics (SYRE) has a market capitalization of $7.65B. The stock trades at 84.6× sales. Over the trailing twelve months it lost $178.92M on revenue of $90.49M and burned $208.94M of free cash flow.
As of its latest reported balance sheet, it holds $162.01M in cash and securities against $0.00 of debt, a net cash position of $162.01M.
Spyre Therapeutics does not currently pay a dividend.
The share price is up 312.7% over the past year. At $90.33 (the Oct 23, 2026 close) it sits within its 52-week range of $21.14 to $110.17, above its 200-day moving average of $70.66.
Based on 14 professional analyst ratings from the past 90 days, the consensus is Buy with an average price target of $122.42, 35.5% above the Oct 23, 2026 close.
Frequently Asked Questions About Spyre Therapeutics
What is the current stock price for SYRE?
As of the Oct 23, 2026 close, SYRE stock trades at $90.33. The 52-week range is $21.15–$110.18, with a day range of $88.69–$91.90.
What is the P/E ratio for SYRE?
The P/E ratio (Price-to-Earnings) for SYRE is shown in the Key Statistics section. This valuation metric helps compare Spyre Therapeutics, Inc. to industry peers.
Does SYRE pay dividends?
Spyre Therapeutics does not currently pay a regular dividend. It reported a net loss over the trailing twelve months, so it has no earnings to distribute. Check the Dividends tab for historical dividend information.
What do analysts recommend for SYRE?
Based on ratings from 14 professional analysts over the last 90 days, the consensus for SYRE is Buy. The average 12-month price target is $122.42, a 35.5% upside from the Oct 23, 2026 close of $90.33.
What is the market cap of SYRE?
As of the Oct 23, 2026 close, Spyre Therapeutics's market capitalization is $7.65B, classifying it as a mid-cap company. Spyre Therapeutics operates in the Healthcare sector within the Biotechnology industry.