Spyre Therapeutics, Inc. (SYRE) Forecast: Analyst Ratings & Targets

Latest SYRE Analyst Ratings & Recommendations

Recent analyst recommendations with rating changes and price target updates (last 90 days)

Date	Analyst	Firm	Action	Rating	Price Target
Apr 17, 2026	Debanjana Chatterjee	Jones Trading	Maintains	Strong Buy	$64.00 → $95.00 +31.00 (48.4%)
Apr 14, 2026	David Nierengarten	Wedbush	Maintains	Buy	$65.00 → $80.00 +15.00 (23.1%)
Apr 14, 2026	David Hoang	Deutsche Bank	Maintains	Strong Buy	$55.00 → $88.00 +33.00 (60.0%)
Apr 14, 2026	Yanan Zhu	Wells Fargo	Maintains	Buy	$50.00 → $90.00 +40.00 (80.0%)
Apr 14, 2026	Colleen Kusy	Baird	Maintains	Buy	$65.00 → $90.00 +25.00 (38.5%)
Apr 14, 2026	Martin Auster	Raymond James	Initiates	Strong Buy	$80.00
Apr 13, 2026	Julian Harrison	BTIG	Maintains	Strong Buy	$70.00 → $98.00 +28.00 (40.0%)
Apr 13, 2026	Thomas Smith	Leerink Partners	Maintains	Buy	$49.00 → $106.00 +57.00 (116.3%)
Apr 13, 2026	Akash Tewari	Jefferies	Maintains	Strong Buy	$47.00 → $85.00 +38.00 (80.8%)
Mar 31, 2026	Julian Harrison	BTIG	Reiterates	Strong Buy	$70.00 → $70.00 +0.00 (0.0%)
Mar 18, 2026	Alex Thompson	Stifel	Maintains	Strong Buy	$70.00 → $92.00 +22.00 (31.4%)
Mar 16, 2026	Julian Harrison	BTIG	Reiterates	Strong Buy	$70.00 → $70.00 +0.00 (0.0%)
Feb 20, 2026	Julian Harrison	BTIG	Reiterates	Strong Buy	$70.00 → $70.00 +0.00 (0.0%)
Feb 20, 2026	Yanan Zhu	Wells Fargo	Maintains	Buy	$40.00 → $50.00 +10.00 (25.0%)

Debanjana Chatterjee

Jones Trading

Strong BuyMaintains

$64.00 → $95.00

Apr 17

David Nierengarten

Wedbush

BuyMaintains

$65.00 → $80.00

Apr 14

David Hoang

Deutsche Bank

Strong BuyMaintains

$55.00 → $88.00

Apr 14

Yanan Zhu

Wells Fargo

BuyMaintains

$50.00 → $90.00

Apr 14

Colleen Kusy

Baird

BuyMaintains

$65.00 → $90.00

Apr 14

Martin Auster

Raymond James

Strong BuyInitiates

$80.00

Apr 14

Julian Harrison

BTIG

Strong BuyMaintains

$70.00 → $98.00

Apr 13

Thomas Smith

Leerink Partners

BuyMaintains

$49.00 → $106.00

Apr 13

Akash Tewari

Jefferies

Strong BuyMaintains

$47.00 → $85.00

Apr 13

Julian Harrison

BTIG

Strong BuyReiterates

$70.00 → $70.00

Mar 31

Alex Thompson

Stifel

Strong BuyMaintains

$70.00 → $92.00

Mar 18

Julian Harrison

BTIG

Strong BuyReiterates

$70.00 → $70.00

Mar 16

Julian Harrison

BTIG

Strong BuyReiterates

$70.00 → $70.00

Feb 20

Yanan Zhu

Wells Fargo

BuyMaintains

$40.00 → $50.00

Feb 20

Frequently Asked Questions

What is the analyst consensus rating for SYRE?

The analyst consensus rating for SYRE is "Strong Buy" based on 10 analyst recommendations.

What is the average price target for SYRE?

The average 12-month price target for SYRE is $90.40, representing an upside of 25.7% from the current price of $71.92.

What do analyst ratings mean?

Analyst ratings indicate investment recommendations: Strong Buy and Buy are bullish signals suggesting the stock may outperform. Hold means the stock is fairly valued. Sell and Strong Sell are bearish signals suggesting potential underperformance. These ratings are based on fundamental analysis and valuation models.

What is a price target?

A price target is an analyst's projection of a stock's fair value over a specific timeframe, typically 12 months. Analysts use fundamental analysis, financial modeling, and industry comparisons to estimate where the stock should trade. Price targets can range from low (conservative) to high (optimistic) estimates.

Spyre Therapeutics, Inc. (SYRE) Analyst Forecast

Analyst Consensus Rating

Consensus Rating

Average Price Target

Latest SYRE Analyst Ratings & Recommendations

Frequently Asked Questions