Septerna, Inc.
SEPNNASDAQHealthcareBiotechnology
As of Oct 22, 2026 close
- Market cap
- $1.84B
- P/E (TTM)
- -
- Forward P/E
- -
- Dividend yield
- -
- 52-week range
- $17.55$51.10
- Volume (live)
- -
- Avg. volume (3M)
- 389.24K
Septerna (SEPN) Stock Price & Financial Analysis
Septerna Stock Price Chart
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Financial Metrics & Key Statistics
Fundamental metrics, valuation ratios, and profitability indicators
| Day's Range | $39.70 - $41.77 |
|---|---|
| 52-Week High | $51.10 |
| 52-Week Low | $17.55 |
| Open | $40.72 |
| Volume (last close) | 251.07K |
| Average Volume (3M) | 389.24K |
| Revenue (TTM) | 98.88M |
|---|---|
| Net Income (TTM) | -24.24M |
| Free Cash Flow (TTM) | 105.10M |
| EPS (TTM) | −$0.54 |
| Profit Margin | -24.51% |
| Operating Margin | -56.68% |
| Return on Equity (ROE) | -6.27% |
| Debt to Equity | 0.06 |
| Annual Dividend | $0.00 |
|---|---|
| Dividend Yield | 0.00% |
| Market Cap | 1.84B |
|---|---|
| Shares Outstanding | 45.04M |
| Price to Sales (P/S) | 18.62 |
| Price to Book (P/B) | 4.76 |
| EV/EBITDA | -40.34 |
| 50-Day MA | $39.30 |
|---|---|
| 200-Day MA | $31.41 |
| 1-Year Change | +87.61% |
Source: Market prices and company fundamentals. Data as of Oct 22, 2026. Data sources and methodology
Septerna at a Glance
As of the Oct 22, 2026 close, Septerna (SEPN) has a market capitalization of $1.84B. The stock trades at 18.6× sales. Over the trailing twelve months it lost $24.24M on revenue of $98.88M and generated $105.10M of free cash flow. Revenue grew 13520.1% year over year.
As of its latest reported balance sheet, it holds $84.66M in cash and securities against $22.55M of debt, a net cash position of $62.12M.
Septerna does not currently pay a dividend.
The share price is up 87.6% over the past year. At $40.88 (the Oct 22, 2026 close) it sits within its 52-week range of $17.55 to $51.10, above its 200-day moving average of $31.41.
Based on 11 professional analyst ratings from the past 90 days, the consensus is Buy with an average price target of $52.88, 29.4% above the Oct 22, 2026 close.
Frequently Asked Questions About Septerna
What is the current stock price for SEPN?
As of the Oct 22, 2026 close, SEPN stock trades at $40.88. The 52-week range is $17.55–$51.10, with a day range of $39.70–$41.77.
What is the P/E ratio for SEPN?
The P/E ratio (Price-to-Earnings) for SEPN is shown in the Key Statistics section. This valuation metric helps compare Septerna, Inc. to industry peers.
Does SEPN pay dividends?
Septerna does not currently pay a regular dividend. It reported a net loss over the trailing twelve months, so it has no earnings to distribute. Check the Dividends tab for historical dividend information.
What do analysts recommend for SEPN?
Based on ratings from 11 professional analysts over the last 90 days, the consensus for SEPN is Buy. The average 12-month price target is $52.88, a 29.4% upside from the Oct 22, 2026 close of $40.88.
What is the market cap of SEPN?
As of the Oct 22, 2026 close, Septerna's market capitalization is $1.84B, classifying it as a small-cap company. Septerna operates in the Healthcare sector within the Biotechnology industry.