Ionis Pharmaceuticals, Inc.
IONSNASDAQHealthcareBiotechnology
As of Oct 22, 2026 close
- Market cap
- $7.26B
- P/E (TTM)
- -
- Forward P/E
- -
- Dividend yield
- -
- 52-week range
- $42.08$86.74
- Volume (live)
- -
- Avg. volume (3M)
- 3.80M
Ionis Pharmaceuticals (IONS) Stock Price & Financial Analysis
Ionis Pharmaceuticals Stock Price Chart
Loading chart...
Financial Metrics & Key Statistics
Fundamental metrics, valuation ratios, and profitability indicators
| Day's Range | $43.41 - $45.15 |
|---|---|
| 52-Week High | $86.74 |
| 52-Week Low | $42.08 |
| Open | $45.02 |
| Volume (last close) | 5.01M |
| Average Volume (3M) | 3.80M |
| Revenue (TTM) | 873.76M |
|---|---|
| Net Income (TTM) | -564.78M |
| Free Cash Flow (TTM) | -562.51M |
| EPS (TTM) | −$3.46 |
| Profit Margin | -64.64% |
| Operating Margin | -68.09% |
| Return on Equity (ROE) | -128.44% |
| Debt to Equity | 5.50 |
| Annual Dividend | $0.00 |
|---|---|
| Dividend Yield | 0.00% |
| Last Dividend Ex-Date | Feb 17, 2000 |
| Market Cap | 7.26B |
|---|---|
| Shares Outstanding | 165.42M |
| Price to Sales (P/S) | 8.31 |
| Price to Book (P/B) | 16.52 |
| EV/EBITDA | 2.14 |
| 50-Day MA | $51.25 |
|---|---|
| 200-Day MA | $68.25 |
| 1-Year Change | −38.59% |
Source: Market prices and company fundamentals. Data as of Oct 22, 2026. Data sources and methodology
Ionis Pharmaceuticals at a Glance
As of the Oct 22, 2026 close, Ionis Pharmaceuticals (IONS) has a market capitalization of $7.26B. The stock trades at 8.3× sales. Over the trailing twelve months it lost $564.78M on revenue of $873.76M and burned $562.51M of free cash flow. Revenue fell 7.4% year over year.
As of its latest reported balance sheet, it holds $350.06M in cash and securities against $2.42B of debt, a net debt position of $2.07B.
Ionis Pharmaceuticals does not currently pay a dividend.
The share price is down 38.6% over the past year. At $43.91 (the Oct 22, 2026 close) it sits near the bottom of its 52-week range of $42.08 to $86.74, below its 200-day moving average of $68.25.
Based on 22 professional analyst ratings from the past 90 days, the consensus is Buy with an average price target of $83.89, 91.0% above the Oct 22, 2026 close.
Frequently Asked Questions About Ionis Pharmaceuticals
What is the current stock price for IONS?
As of the Oct 22, 2026 close, IONS stock trades at $43.91. The 52-week range is $42.08–$86.74, with a day range of $43.41–$45.15.
What is the P/E ratio for IONS?
The P/E ratio (Price-to-Earnings) for IONS is shown in the Key Statistics section. This valuation metric helps compare Ionis Pharmaceuticals, Inc. to industry peers.
Does IONS pay dividends?
Ionis Pharmaceuticals does not currently pay a regular dividend. It reported a net loss over the trailing twelve months, so it has no earnings to distribute. Check the Dividends tab for historical dividend information.
What do analysts recommend for IONS?
Based on ratings from 22 professional analysts over the last 90 days, the consensus for IONS is Buy. The average 12-month price target is $83.89, a 91.0% upside from the Oct 22, 2026 close of $43.91.
What is the market cap of IONS?
As of the Oct 22, 2026 close, Ionis Pharmaceuticals's market capitalization is $7.26B, classifying it as a mid-cap company. Ionis Pharmaceuticals operates in the Healthcare sector within the Biotechnology industry.