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Upstream Bio, Inc.

UPBNASDAQHealthcareBiotechnology

$2.76Today:- (-)1Y −83.93%

As of Oct 16, 2026 close

Market cap
$183.89M
P/E (TTM)
-
Forward P/E
-
Dividend yield
-
52-week range
$3.29$33.68
Volume (live)
-
Avg. volume (3M)
875.05K

Upstream Bio, Inc. (UPB) Analyst Forecast

Analyst consensus ratings, 12-month price targets, and expert recommendations for Upstream Bio, Inc. stock.

Analyst Consensus Rating

Investment consensus from 6 professional research analysts

Consensus Rating

Buy
Based on 6 unique analysts
(7 total ratings in last 90 days)
Medium Confidence∞:1 Buy/Sell

Average Price Target

$22.25
+706.16% upside

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Strong Sell
Sell
Hold
Buy
Strong Buy

Latest UPB Analyst Ratings & Recommendations

Recent analyst recommendations with rating changes and price target updates (last 90 days)

Matt Phipps
William Blair
BuyMaintains
-
Kate Dellorusso
LifeSci Capital
BuyMaintains
$19.00
Matthew Caufield
HC Wainwright
BuyReiterates
$36.00
Tessa Romero
JP Morgan
HoldMaintains
$8.00 → $9.00
Danielle Brill
Truist
BuyMaintains
$43.00 → $25.00
Zacks Equity Research
Zacks Equity Research
BuyInitiates Coverage
-
Danielle Brill
Truist
BuyMaintains
$43.00 → $25.00

Source: Professional analyst ratings and price targets from the last 90 days. Data as of Sep 8, 2026. Data sources and methodology

Frequently Asked Questions

What is the analyst consensus rating for UPB?

The analyst consensus rating for UPB is Buy, based on the latest ratings from 6 analysts over the last 90 days.

What is the average price target for UPB?

The average 12-month price target for UPB is $22.25, representing an upside of 706.2% from the Oct 16, 2026 close of $2.76.

What do analyst ratings mean?

Analyst ratings indicate investment recommendations: Strong Buy and Buy are bullish signals suggesting the stock may outperform. Hold means the stock is fairly valued. Sell and Strong Sell are bearish signals suggesting potential underperformance. These ratings are based on fundamental analysis and valuation models.

What is a price target?

A price target is an analyst's projection of a stock's fair value over a specific timeframe, typically 12 months. Analysts use fundamental analysis, financial modeling, and industry comparisons to estimate where the stock should trade. Price targets can range from low (conservative) to high (optimistic) estimates.