Upstream Bio (UPB) Financial Ratios

For fiscal 2025 (fiscal year ended Dec 31, 2025), Upstream Bio had return on equity of -35.4% (down from -21.7%), debt-to-equity of 0.00 (unchanged), a current ratio of 26.15 (down from 44.63) and return on assets of -24.0% (down from -16.2%). A current ratio of 26.15 means current assets exceed current liabilities.

Upstream Bio Financial Ratios Analysis

Valuation, profitability, leverage, and liquidity ratios

Income Statement Balance Sheet Cash Flow Ratios

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Breakdown	FY 2025	FY 2024	FY 2023	FY 2022
Period ending	Dec 2025	Dec 2024	Dec 2023	Dec 2022
Valuation Ratios
P/S Ratio	514.07	371.78	-	-
P/B Ratio	4.32	1.88	-	-
Price/Tangible Book	4.32	1.88	-	-
Enterprise Value Ratios
EV/Revenue	384.07	440.20	-	-
Profitability & Returns
Return on Equity (ROE)	-35.43%	-21.74%	-35.88%	-
Return on Assets (ROA)	-23.99%	-16.23%	-36.96%	-
Return on Capital Employed (ROCE)	-47.10%	-16.50%	-36.20%	-175.50%
Leverage & Solvency Ratios
Debt/Equity	0.00	0.00	0.00	0.01
Liquidity Ratios
Current Ratio	26.15	44.63	17.96	3.77
Quick Ratio	25.56	43.93	16.89	3.60
Efficiency Ratios
Asset Turnover	0.01	0.01	0.04	-
Yield & Distribution Ratios
Earnings Yield	-9.78%	-7.13%	-	-
FCF Yield	-9.09%	-6.77%	-	-
Buyback Yield	-293.59%	-363.22%	-5.49%	-

Source: Company financial statements from annual and quarterly filings. Data as of Jun 30, 2026. Data sources and methodology

Frequently Asked Questions About Upstream Bio Financial Ratios

What is Upstream Bio's return on equity?

Upstream Bio's return on equity (ROE) was -35.4% for fiscal 2025 (period ended Dec 31, 2025). It was -21.7% a year earlier.

What is Upstream Bio's debt-to-equity ratio?

Upstream Bio's debt-to-equity ratio was 0.00 for fiscal 2025 (period ended Dec 31, 2025). It was 0.00 a year earlier.

What is return on equity (ROE)?

Return on equity is net income divided by shareholders' equity. It measures how much profit a company generates from the capital its shareholders have invested. Full definition